First-time users can open EndNote by clicking Start > Programs > EndNote. Upon opening, users will have a choice to make regarding starting a new library or importing/opening an existing library. For a first time user, select New Library. Once created, citatins can be imported in three principle means, as explained in the Create References tab above.
Once an EndNote Library is created, it is generally a good idea to make a copy of the library so data can be retrieved if errors are encountered. This can be done through the Save a Copy, Exporting, and Creating a Compressed Library functions. Syncing your library with the EndNote Web version is also an option.